TSLP - thymic stromal lymphopoietin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85480

About TSLP

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,070,062-111,078,026 (from NCBI)

This gene has 3 transcripts (splice variants) and 65 orthologues. Broad expression in gall bladder (RPKM 3.6), liver (RPKM 3.0) and 15 other tissues.

Summary

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying Antibacterial and Antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]

TSLP Products (2)

mRNA	Protein	Name
NM_033035.5	NP_149024.1	thymic stromal lymphopoietin isoform 1 precursor
NM_138551.5	NP_612561.2	thymic stromal lymphopoietin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	11418668	GOA
enables cytokine activity	IMP IMP: Inferred from mutant phenotype	17242164	GOA
enables interleukin-7 receptor binding	IMP IMP: Inferred from mutant phenotype	11480573	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	24850429	GOA
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11480573	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10881176	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	24850429	GOA
involved in defense response to fungus	IDA IDA: Inferred from direct assay	24850429	GOA
involved in interleukin-7-mediated signaling pathway	IDA IDA: Inferred from direct assay	11480573	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11480573	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11418668	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11480573	GOA
involved in positive regulation of chemokine (C-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	11418668	GOA
involved in positive regulation of cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	11418668	GOA
involved in positive regulation of granulocyte colony-stimulating factor production	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	17242164	GOA
involved in positive regulation of mast cell activation	IMP IMP: Inferred from mutant phenotype	17242164	GOA
NOT involved in positive regulation of receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	24850429	GOA
involved in positive regulation of receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	11418668	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11418668	GOA
located in extracellular region	IMP IMP: Inferred from mutant phenotype	11480573	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	11418668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSLP Protein Structure

TSLP

0
100
159 a.a.

Protein Preferred Names	Protein Names
thymic stromal lymphopoietin

Recombinant TSLP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7057	TSLP Protein, Human	Q969D9-1 (Y29-Q159)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70818	TSLP Protein, Human (HEK293, His)	Q969D9-1 (Y29-Q159)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78224	TSLP Protein, Human (Biotinylated, HEK293, His-Avi)	Q969D9-1 (Y29-Q159)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78225	TSLP Protein, Human (Biotinylated, R127A, R130A, HEK293, His-Avi)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78532	TSLP Protein, Human (HEK293, His-Avi)	Q969D9-1 (Y29-Q159)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78533	TSLP Protein, Human (R127A, R130A, HEK293, His-Avi)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78658	TSLP Protein, Human (R127A, R130A, HEK293, His)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78659	TSLP Protein, Human (R127A, R130A, HEK293, mFc)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700601	TSLP Protein, Human (HEK293, His-Myc)	Q969D9-1 (Y29-Q159)	≥ 90%, as determined by reducing SDS-PAGE.

TSLP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811326	TSLP Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cryoglobulinemia	Cryoimmunoglobulinaemia
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Membranoproliferative Glomerulonephritis	Mesangiocapillary Glomerulonephritis Dense Deposit Disease Membranoproliferative Glomerulonephritis Type 2 Primary Membranoproliferative Glomerulonephritis Mesangiocapillary Glomerulonephritis, Type Ii Glomerulonephritis, Membranoproliferative Chronic Glomerulonephritis, Lobular Lobular Glomerulonephritis Ddd Glomerulonephritis Membranoproliferative Type 2 Mpgn 2 Membranoproliferative Glomerulonephritis Type Ii Mesangiocapillary Glomerulonephritis Type 2 Mpgn Primary Mpgn Glomerulonephritis Membranoproliferative Membranoproliferative Glomerulonephritis, Type Ii
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Cryoglobulinemia, Familial Mixed	Cryoglobulinemic Vasculitis Essential Mixed Cryoglobulinemia Mixed Cryoglobulinemia Essential Cryoglobulinemia Primary Cryoglobulinemia Meltzer Syndrome Familial Mixed Cryoglobulinemia
Esophagitis	Acute Esophagitis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
T2-Low Asthma	Type 2 Low Endotype
Respiratory Allergy	Airway Allergy
Chronic Asthma
Eczema Herpeticum	Herpes Simplex Dermatitis Herpes Simplex Eyelid Dermatitis Kaposi Varicelliform Eruption Herpes Simplex Dermatitis Of Eyelid Herpes Simplex Virus Dermatitis Herpes Simplex Virus Eyelid Dermatitis
Nasal Cavity Disease	Disorder Of Nasal Cavity
Rhinitis	Runny Nose
T2-High Asthma	Type 2 High Endotype
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Legume Allergy	Fabaceae Allergy
Acute Asthma
Occupational Asthma
Environmental Induced Asthma	Irritant Asthma
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Intrinsic Asthma	Non-Atopic Asthma
Neurodermatitis
Peanut Allergy	Allergy To Peanuts Peanut Allergic Reaction Allergies Peanut Peanut Hypersensitivity
Fruit Allergy	Allergy To Fruit
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Chronic Conjunctivitis
Dermatitis, Atopic, 3	ATOD3 Dermatitis, Atopic, Susceptibility To, 3 Atopic Dermatitis 3 Dermatitis, Atopic, With Asthma Dermatitis, Atopic 3 Atopic Dermatitis With Asthma
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Intermittent Asthma
Common Cold	Acute Coryza Acute Nasopharyngitis Acute Rhinitis Acute Viral Rhinopharyngitis Nasopharyngitis - Acute Nasopharyngitis, Acute Rhino-Sinusitis Rhinosinusitis Common Colds Acute Infective Rhinitis Cold Coryza Head Cold Infective Nasopharyngitis Rhinopharyngitis Acute Nasal Catarrh Infective Rhinitis Acute Nasopharyngeal Catarrh Infective Nasopharyngitis Nos Nasopharyngitis Nos Epipharyngitis Mucositis Nos Inflammatory Disease Of Mucous Membrane Mucosal Inflammation
Allergic Conjunctivitis	Conjunctivitis Allergic Conjunctivitis, Allergic Allergen-Induced Conjunctivitis Seasonal Allergic Conjunctivitis Perennial Allergic Conjunctivitis Spring Conjunctivitis Acute Allergic Conjunctivitis
Goat Milk Allergy	Capra Hircus Milk Allergy
Glomerulonephritis	Bright'S Disease
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Egg Allergy	Allergy To Eggs Allergies Egg Egg Hypersensitivity
Eosinophilic Gastritis	Eosinophilic Enteropathy
Childhood-Onset Asthma	Childhood Asthma Asthma Childhood
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Irritant Dermatitis	Irritant Contact Dermatitis Primary Irritant Dermatitis Dermatitis, Irritant Contact Dermatitis, Irritant Irritant Contact Eczema Icd - [Irritant Contact Dermatitis] Irritant Contact Dermatitis, Unspecified Cause Non-Allergic Contact Dermatitis Irritant Contact Eczema Due To Wet Work Irritant Contact Dermatitis Due To Detergents Irritant Contact Eczema Due To Solvents Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants Irritant Contact Eczema Due To Cosmetics Or Emollients Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials Irritant Contact Eczema Due To Plants Or Other Vegetable Matter Irritant Contact Eczema Due To Foods Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids Irritant Contact Eczema Due To Saliva Irritant Contact Eczema Due To Incontinence Incontinence-Associated Dermatitis
Persistent Severe Asthma
Near-Fatal Asthma
Pneumothorax, Primary Spontaneous	Primary Spontaneous Pneumothorax Spontaneous Pneumothorax Familial Spontaneous Pneumothorax PSP Pneumothorax
Trichinosis	Trichinellosis Human Trichinellosis Trichiniasis Trichinella Spiralis Infection Infection With Trichinella Trichinelliasis Trichinella Spiralis Infestation
Milk Allergy	Milk Allergic Reaction Milk Hypersensitivity Allergy Milk
Conjunctival Disease	Conjunctival Diseases Conjunctival Disorder
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Exercise-Induced Bronchoconstriction	Exercise-Induced Asthma Asthma Exercise-Induced
Integumentary System Disease
Adult-Onset Severe Asthma
Dermatitis, Atopic, 5	ATOD5 Atopic Dermatitis 5 Dermatitis, Atopic, Susceptibility To, 5 Dermatitis, Atopic 5
Mite Infestation	Mite Infestations Acariasis Infestation By Mites Nos
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis
Paranasal Sinus Disease	Paranasal Sinus Diseases Disorder Of Nasal Sinus
Chronic Ethmoiditis	Chronic Ethmoidal Sinusitis Chronic Ethmoid Sinusitis Ethmoidal Sinusitis - Chronic
Upper Respiratory Tract Disease
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99366A	Tezepelumab (anti-TSLP)		≥99.0%	Phase 4
HY-P990748	Lunsekimig	Inhibitor	99.00%	Phase 3
HY-P990906	Bosakitug		99.00%	Phase 3
HY-P990933	Ocankitug		≥99.0%	Phase 3
HY-P991471	GB-0895	Inhibitor	96.67%	Phase 3
HY-P990023	Bempikibart	Antagonist	98.00%	Phase 2
HY-P99872	Ecleralimab	Inhibitor	97.35%	Phase 2
HY-P991717	Sunakiment	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163731	EGR-1-IN-1	Inhibitor	99.07%	Unkown
HY-150207	RBN-3143	Inhibitor	99.29%	Unkown
HY-170415	EGR-1-IN-3	Inhibitor	99.13%	Unkown
HY-207120	TSLP-IN-1	Inhibitor	99.67%	Unkown
HY-206870	BP79	Inhibitor	/	Unkown
HY-158990	GE1111		95.73%	Unkown
HY-181006	TSLP modulator-1	Inhibitor	99.61%	Unkown
HY-W341962	Halometasone	Inhibitor	98.47%	Unkown
HY-181576	ROCK2-IN-14	Inhibitor	/	Unkown
HY-182362	TK-285		/	Unkown
HY-404647	FK3453	Inhibitor	/	Unkown
HY-RS15153	TSLP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3989	Haplopine		99.49%	Unkown
HY-RS16628	Tslp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23063	Tslp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990774	Verekitug	Inhibitor	97.00%	Unkown
HY-P990150	Anti-Mouse TSLP Antibody (28F12)	Inhibitor	98.395%	Unkown
HY-P991162	Tilrekimig	Inhibitor	96%	Unkown
HY-P991684	Felcorekibart	Inhibitor	99.637%	Unkown
HY-P991720	Tepilukimig	Inhibitor	95.57%	Unkown
HY-P992474	TAVO101		/	Unkown
HY-P990535	Anti-TSLP Antibody	Inhibitor	/	Unkown
HY-P992378	HZ-1127	Inhibitor	/	Unkown
HY-P992447	QX008N	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSLP	MGD	MGI:1855696
Canis familiaris	TSLP	VGNC	VGNC:53251
Macaca mulatta	TSLP	VGNC	VGNC:79871
Rattus norvegicus	TSLP	RGD	RGD:1586479
Felis catus	TSLP	VGNC	VGNC:66621
Others	TSLP	NCBI